BMJ5d
Diagnosis of osteoporosis in statin-treated patients is dose-dependent
Objective Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a role in the pathogenesis of osteoporosis, is not entirely known so far. Consequently, this study was set out to ...
BMJ5d
Extracting immunological and clinical heterogeneity across autoimmune rheumatic diseases by cohort-wide immunophenotyping
Correspondence to Prof. Yukinori Okada, Department of Statistical Genetics, Osaka University School of Medicine Graduate School of Medicine, Suita, Osaka, Japan; yuki-okada{at}m.u-tokyo.ac.jp; Prof.
BMJ3d
Initial glucocorticoid bridging in rheumatoid arthritis: does it affect glucocorticoid use over time?
Objectives To compare the use of glucocorticoids (GC) over time in patients with rheumatoid arthritis (RA) who were or were not treated initially with GC bridging therapy. Methods Data from the BeSt, ...
BMJ4d
Pathogenic neuropsychiatric effect of stress-induced microglial interleukin 12/23 axis in systemic lupus erythematosus
Correspondence to Professor Masaaki Murakami, Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan; ...
BMJ4d
Global, regional and national burden of rheumatoid arthritis 1990–2017: a systematic analysis of the Global Burden of Disease study 2017
Objectives To provide the level and trends of prevalence, incidence and disability adjusted life years (DALYs) for rheumatoid arthritis (RA) in 195 countries from 1990 to 2017 by age, sex, ...
BMJ3d
Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)
Aims Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low ...
BMJ5d
Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese
Correspondence to Dr Yukinori Okada, Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan; yokada{at}sg.med.osaka-u.ac.jp Objective Alteration of the ...
BMJ5d
Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers
Objectives To estimate lifetime risk of developing rheumatoid arthritis-associated interstitial lung disease (RA-ILD) with respect to the strongest known risk factor for pulmonary fibrosis, a MUC5B ...
BMJ5d
Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression
1 University of Leeds Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, UK Background The human enthesis conventional T cells are poorly characterised. Objectives To study the biology ...
BMJ3d
Transplacental passage of belimumab during pregnancy and follow-up of a child exposed in utero
A recent report from the Belimumab Pregnancy Registry (NCT01532310) analysed available data on the consequences of belimumab (BEL) use in pregnant women with systemic lupus erythematosus (SLE).1 ...
BMJ5d
Baseline use of hydroxychloroquine in systemic lupus erythematosus does not preclude SARS-CoV-2 infection and severe COVID-19
Correspondence to Dr Maximilian F Konig, Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA; konig{at}jhmi.edu; Dr Philip C Robinson, The University of ...
BMJ7d
Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis
Objective Rheumatoid arthritis (RA) immunopathogenesis revolves around the presentation of poorly characterised self-peptides by human leucocyte antigen (HLA)-class II molecules on the surface of ...