Rookie running back Isaac Guerendo was carted off the field early in the 49ers’ season finale in Arizona against the Cardinals with a leg injury.

Rookie running back Isaac Guerendo was carted off the field early in the 49ers’ season finale in Arizona against the ...

Per head coach Kyle Shanahan, San Francisco 49ers running back Isaac Guerendo (knee, ankle) has likely picked up an MCL ...

George Kittle and Kyle Juszczyk said after the Sunday's season-ending loss to Arizona that they hope their futures remain in ...

San Francisco running back Isaac Guerendo exited the 49ers' season finale versus the Arizona Cardinals just four plays into ...

San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the first offensive drive. The ...

Unfortunately, San Francisco 49ers' running back Isaac Guerendo was carted off the field early in the first quarter.

San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has ...

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers' season finale versus the Arizona ...

The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have started ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...