General Hospital ’s longest recurring actor and portrayer of matriarch Monica Quartermaine, Leslie Charleson, has died at 79. Since the show’s executive producer Frank Valentini shared the news on Sunday, fans and fellow cast members have shared their reactions to the significant loss.

Soap opera veteran Leslie Charleson, who played Monica Quartermaine on "General Hospital," has died at the age of 79.

Ms. Charleson played Dr. Monica Quartermaine, a cardiologist and family matriarch, on the daytime series for 46 years.

Television lost one of its most influential figures with the passing of Leslie Charleson at 79. Her portrayal of Monica Quartermaine on "General Hospital"

Leslie Charleson, who played popular character Dr. Monica Quartermaine for almost 50 years on “General Hospital,” has died. She was 79.

Leslie Charleson, who played cardiologist Monica Quartermaine on "General Hospital" for five decades, has died, according to the soap opera's producer. She was 79.

Leslie Charleson, who joined "General Hospital" as Monica Quartermaine and made her last appearance just over a year ago, has died, the ABC show announced Sunday on Instagram.

Leslie Charleson, who played Dr. Monica Quartermaine on “General Hospital” for nearly 50 years, has passed away at the age of 79, leaving behind a legacy of enduring love and respect

Jason Quartermaine may not have been Monica's biological son, but she raised him from the time he was a baby to the time he started college as a pre-med student. In fact, some wou

General Hospital’s Jason recently sided with Tracy and the Quartermaines over Sonny. Will his loyalty wind up netting him a big surprise gift?

Leslie Charleson, whose Dr. Monica Quartermaine was the longest-tenured character on “General Hospital,” has died. She was 79. Charleson died of complications from a long illness, said ABC News, which broadcasts the long-running soap opera.