A biomarker test identified tau pathology in Alzheimer's disease before fibrillary tangles developed. Neurofibrillary tangle formation can be prevented by targeting intermediate soluble tau assemblies ...

Researchers have discovered the mechanism by which neurofibrillary tangles spread through the brain of Alzheimer's patients is via connected neurons, and these findings reveal a major disease etiology ...

A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are due to the accumulation of abnormal, ...

Alzheimer's disease is a progressive neurodegenerative disorder that slowly impairs memory, affects thinking skills, and eventually interferes with daily functioning. It is the most common cause of ...

Soon after the characterization of amyloid-β plaques in the brains of people with Alzheimer’s disease in 1984, scientists determined the composition of the second pathological hallmark spotted by ...

A new Northwestern Medicine study showed cognitive SuperAgers have resistance to the development of fibrous tangles in a brain region related to memory and which are known to be markers of Alzheimer's ...

Just as gravity explains how two distant objects can sway each other’s movement in space, synaptic connections may explain how amyloid plaques coax distant tau tangles to spread in the brain. This is ...

Researchers have shown they can detect cognitive decline related to heavy alcohol use even before clinical dementia symptoms appear, according to a study published in Alcohol: Clinical and ...

Biomarkers of Alzheimer’s disease are ready for widespread use in clinical trials. In this webinar, learn how next-gen CAR-T design targets solid tumors and which tools ease the path from discovery to ...

In Europe and the U.S., proportionately fewer people are developing dementia now than in the past. Is this driven by less-prevalent Alzheimer's disease pathology? No, say researchers led by Francine ...