Through six weeks of the NFL season, it's hard to find a team who doesn't have a serious question mark. Two weeks ago, we would've been raving about the undefeated Eagles and Bills. Now both teams have lost two straight games.

The San Francisco 49ers (4-2) are favored by 1.5 points against the Atlanta Falcons (3-2) on October 19, 2025, starting at 8:20 p.m. ET, airing on NBC.

The Patriots are solid favorites, expected to win by at least a touchdown (currently -7).