BUFFALO, N.Y. -- During normal growth and development, cells in the body communicate with each other through protein receptors on the cell surface. Among the proteins used for this communication are ...

Individuals with glioblastoma multiforme (GBM), one of the most aggressive types of brain tumor, have an extremely poor prognosis. Although pre-clinical studies indicated therapeutics inhibiting a ...

Using primary samples from the InterMEL study, a retrospective cohort of cases with specimens collected from an international consortium with participating institutions throughout the United States ...

In preclinical proteomics, speed and accuracy are paramount. Increasingly, scientists must capture more data in less time while consuming minimal sample. Given the throughputs required for efficient ...

Researchers from The Cancer Genome Atlas (TCGA) Research Network have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer.

Metazoans use a handful of highly conserved signaling pathways to create a signaling backbone that governs development. How these few signals have such a versatile action likely depends upon the ...

Cellular functions rely on several communications networks that allow cells to rapidly respond to signals affecting the organism. A new study published in the prestigious journal Molecular Cell has ...

Individuals with one of the most aggressive types of brain tumor have an extremely poor prognosis. Although some patients with GBM respond to treatment with drugs known as RTK inhibitors, most ...

Clinical Targeted Next-Generation Panel Sequencing Reveals MYC Amplification Is a Poor Prognostic Factor in Osteosarcoma Using primary samples from the InterMEL study, a retrospective cohort of cases ...