Most cells in the human body carry the entire genome within their nucleus, and as cells divide, age, or are exposed to environmental stresses like UV rays, the DNA in that nucleus can become damaged.

Micronuclei, which are small nucleus-like structures within cells, are commonly associated with tumors. Now, researchers from Tsukuba, Japan have developed an automated computer program that can ...

Numerous errors in chromosome segregation during cell division can lead to the formation of micronuclei, even if there isn’t actual mis-segregation of the chromosomes. These events are not mutually ...

Reactive oxygen species (ROS) from mitochondria are key drivers of genetic chaos in cancer by causing the collapse of micronuclear envelopes, a process that fuels the chromosomal instability (CIN) ...

In 2022, on the alpine shores of Lake Maggiore in northern Italy, longtime friends Samuel Bakhoum, M.D., Ph.D., and Stefano Santaguida, Ph.D., were catching up. Pandemic restrictions had prevented the ...

The two colored dots outside of this breast cancer cell's primary nucleus indicate the presence of micronuclei. A new study investigated how these micronuclei contribute to epigenetic dysregulation in ...

Researchers have created a novel automated program that accurately and quickly counts micronuclei in stained images. Micronuclei are small nucleus-like structures that are markers of pathologies such ...

Within the hallowed walls of the cell, conflict simmers; a tenuous peace, and perhaps its very survival, rest on the slimmest of margins. Housed within the cell’s inner sanctum – the nucleus – is its ...

Cells possess an innate immune system that defends against invasive pathogens. Previous studies have mapped out the cytoplasmic cGAS-STING pathway in the cytoplasm, known for responding to foreign ...