Mice with inducible reporter genes allow systemic profiling of gene expression throughout the brain. Researchers led by Hongkui Zeng at the Allen Brain Institute have created and characterized ...

Cre-loxP, a powerful tool for preclinical cancer research, possesses intrinsic pitfalls that can alter result accuracy, according to an editorial paper in Oncoscience. Cancer and other diseases could ...

“One limitation [of Cre-LoxP], the focus of this editorial, is the potential loss of fidelity of Cre recombinase expression especially in the context of modeling cancer in mice.” “It is based on ...

A team of Chinese researchers has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August ...

(Nanowerk News) A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing ...