The Bills are playing their first home game since 2016 without Sean McDermott. Here's more about Buffalo's decision to part with its long-time coach.

The Lions have plenty of firepower, too. Jahmyr Gibbs should be heavily involved against a Bills defense that had trouble slowing down the Texans. Jared Goff also has top wideout Amon-Ra St. Brown to lean on.

The Detroit Lions travel to Buffalo to take on the Bills on Thursday night. Here are three key stats that should tell the story of the game.

Brady took a minimalist approach the night before the Bills’ opener, but the first-year coach has his players' attention.

Safety Cole Bishop (knee, groin), running back Ty Johnson (hamstring), and defensive lineman T.J. Sanders (knee, illness) are all listed as questionable to face the Lions on Thursday night. The Bills will be the home team and they’re playing their first regular season game at the new Highmark Stadium.

Thursday night promises to deliver plenty of fireworks between two of the league's top teams. As kickoff nears, here's where to watch the Lions at the Bills on Thursday night in prime time: Veteran play-by-play man Al Michaels is on the call alongside analyst Kirk Herbstreit. The pair will be joined by Kaylee Hartung reporting from the sidelines.

The Bills play their first regular-season game at Highmark Stadium as they host the Lions in prime time.

This article was originally published on www.si.com/nfl/lions/onsi as Spot the Ball: 10 Thoughts Ahead of Lions Week 2 Matchup With Bills.

The Bills’ Canadian anthem salute is rooted in business and decades of cross-border fandom. In this political moment, it means more.